1051896-90-2Relevant academic research and scientific papers
Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series
Barlaam, Bernard,Ducray, Richard,Brempt, Christine Lambert-Van Der,Plé, Patrick,Bardelle, Catherine,Brooks, Nigel,Coleman, Tanya,Cross, Darren,Kettle, Jason G.,Read, Jon
scheme or table, p. 2207 - 2211 (2011/05/15)
Optimization of our bis-anilino-pyrimidine series of EphB4 kinase inhibitors led to the discovery of compound 12 which incorporates a key m-hydroxymethylene group on the C4 aniline. 12 displays a good kinase selectivity profile, good physical properties a
