1051929-83-9Relevant academic research and scientific papers
1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)
Therrien, Eric,Larouche, Guillaume,Manku, Sukhdev,Allan, Martin,Nguyen, Natalie,Styhler, Sylvia,Robert, Marie-France,Goulet, Anne-Christine,Besterman, Jeffrey M.,Nguyen, Hannah,Wahhab, Amal
scheme or table, p. 6725 - 6732 (2010/06/12)
We have identified the N1-benzyl-N2-methylethane-1,2-diamine unit as a substitute for the (S)-alanine benzylamide moiety for the design of co-activator associated arginine methyltransferase 1 (CARM1) inhibitors. The potency of these
SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS)
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Page/Page column 92-93, (2008/12/08)
The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. Said compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
