1051967-68-0

Basic information

• Product Name: 2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-yl)ethan- 1- one
• Synonyms: 2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-yl)ethan- 1- one
• CAS NO: 1051967-68-0
• Molecular Weight: 243.185
• Mol File: 1051967-68-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-yl)ethan- 1- one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-yl)ethan- 1- one(1051967-68-0)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-yl)ethan- 1- one(1051967-68-0)

Safety Data

• Hazardous Substances Data: 1051967-68-0(Hazardous Substances Data)

Usage

General Description

2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-yl)ethan-1-one is a chemical compound with the molecular formula C11H9F3NO2. It is a yellow crystalline solid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-yl)ethan- 1- one is known for its ability to act as a building block for the creation of various heterocyclic compounds, which are important in the development of new drugs and agricultural products. Its structure contains a trifluoromethyl group, an indole ring, and a methoxy group, making it a versatile and valuable component in chemical reactions. Additionally, this compound has been studied for its potential biological activities and pharmacological properties, showing promise in various fields of science and medicine.

Upstream product

• 1006-94-6 5-methoxylindole 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 10242-01-0 5-Methoxyindole-3-carboxylic acid 
• 1417717-56-6 1,1,1-trifluoro-2-(5-methoxy-1H-indol-3-yl)-4-phenylbut-3-yn-2-ol 
• 1404536-52-2 [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride 
• 1404532-97-3 sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate 
• 1404532-65-5 {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetic acid methyl ester 

Relevant articles and documents

High-throughput screening of bioactive compounds via new catalytic reaction in the pooled mixture

To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton.

A concise and regioselective synthesis of 6-bromo-5-methoxy-1H-indole-3-carboxylic acid and its derivatives: Strategic development toward core moiety of Herdmanine D

A concise, regioselective and highly efficient strategy for the construction of 6-bromo-5-methoxy-1H-indole-3-carboxylic acid has been developed through trifluoroacetylated indole driven hydrolysis. The developed protocol has the advantage of selectively directing bromine substituent on one position. The formation of this regioselective product was confirmed by 1HNMR data. The attractive feature of this new strategy is that the 6-bromo-5-methoxy-1H-indole-3-carboxylic acid is an important scaffold of anti-inflammatory naturally occurring compound Herdmanine D. Furthermore, bromo indoles bearing carboxylic acid group were further functionalized in amide derivatives by using various aromatic/aliphatic amines through ultrasonic irradiation.

N -[6-(4-Butanoyl-5-methyl-1 H -pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1 H -indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization process leading to the identification of the preclinical candidate SAR216471. It is a potent, highly selective, and reversible P2Y12 receptor antagonist and by far the most potent inhibitor of ADP-induced platelet aggregation among the P2Y12 antagonists described in the literature. SAR216471 displays potent in vivo antiplatelet and antithrombotic activities and has the potential to differentiate from other antiplatelet agents.