1052104-33-2Relevant academic research and scientific papers
Ring expansion of lactones and lactams via propiolate 1-carbon intercalation
Grant, Tina N.,Benson, Chantel L.,West
supporting information; experimental part, p. 3985 - 3988 (2009/05/30)
(Chemical Equation Presented) Readily available five- and six-membered lactones and N-sulfonyllactams undergo efficient addition of t-butyl propiolate, and the resulting adducts undergo cycloisomerization to six- and seven-membered cyclic ethers or amines in the presence of pyridinium acetate. The ring expansion process occurs in generally good yields and is proposed to involve a nucleophilic catalysis mechanism.
