1052148-20-5Relevant academic research and scientific papers
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study
Lacivita, Enza,Podlewska, Sabina,Speranza, Luisa,Niso, Mauro,Sata?a, Grzegorz,Perrone, Roberto,Perrone-Capano, Carla,Bojarski, Andrzej J.,Leopoldo, Marcello
, p. 363 - 379 (2016/07/06)
The 5-HT7 serotonin receptor is revealing a promising target for innovative therapeutic strategies of neurodevelopmental and neuropsychiatric disorders. Here, we report the synthesis of thirty long-chain arylpiperazine analogs of the selective
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1- piperazinehexanamides: Influence on lipophilicity and 5-HT7 receptor activity. Part III
Leopoldo, Marcello,Lacivita, Enza,De Giorgio, Paola,Fracasso, Claudia,Guzzetti, Sara,Caccia, Silvio,Contino, Marialessandra,Colabufo, Nicola A.,Berardi, Francesco,Perrone, Roberto
experimental part, p. 5813 - 5822 (2009/09/08)
Starting from the previously reported 5-HT7 receptor agents 4-7 with N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamide structure, the 1-(2-methylthiophenyl)-, 1-(2-diphenyl)-, 1(2-isopropylphenyl)-, and 1-(2-methoxyphenyl)pipe
