10522-19-7Relevant articles and documents
Total Synthesis of the Flavonoid Natural Product Houttuynoid A
Jian, Jie,Fan, Jilin,Yang, Hui,Lan, Ping,Li, Manmei,Liu, Peijun,Gao, Hao,Sun, Pinghua
, p. 371 - 377 (2018)
The first total synthesis of the antiviral flavonoid houttuynoid A (1) has been achieved from aryl ketone 6 and benzofuran aldehyde 5 in nine linear steps. The C6-C3-C6 structure of the flavonoid was synthesized by an I2-catalyzed oxa-Michael addition of a chalcone intermediate, generated by the Claisen-Schmidt condensation of 5 and 6. This work provides a method for the synthesis of houttuynoids and provides a reference for the synthesis of the remaining members of the houttuynoid family.