1052213-63-4Relevant academic research and scientific papers
Formation of γ-lactones through CAN-mediated oxidative cleavage of hemiketals
Jacobine, Alexander M.,Lin, Weimin,Walls, Bethany,Zercher, Charles K.
, p. 7409 - 7412 (2008)
(Chemical Equation Presented) The generation of substituted γ-lactones can be accomplished through application of a tandem chain extension-aldol reaction, followed by CAN-mediated oxidative cleavage of the aldol product. The oxidative cleavage requires the intermediacy of a hemiketal and the presence of an α-heteroatom. Formation of the γ-lactone through the oxidative cleavage is used to assign stereochemistry of the aldol reaction and as the final step in a short synthesis of members of the phaseolinic acid family of natural products.
