1052216-02-0Relevant articles and documents
"nok": A phytosterol-based amphiphile enabling transition-metal-catalyzed couplings in water at room temperature
Klumphu, Piyatida,Lipshutz, Bruce H.
, p. 888 - 900 (2014/03/21)
The third-generation designer amphiphile/surfactant, "Nok" (i.e., SPGS-550-M; β-sitosterol methoxypolyethyleneglycol succinate), soon to be commercially available from Aldrich, can be prepared in two steps using an abundant plant feedstock and β-sitosterol, together with succinic anhydride and PEG-550-M. Upon dissolution in water, it forms nanomicelles that serve as nanoreactors, which can be characterized by both cryo-TEM and dynamic light scattering analyses. Several transition-metal-catalyzed reactions have been run under micellar conditions to evaluate this surfactant relative to results obtained in nanoparticles composed of TPGS-750-M (i.e., a second-generation surfactant). It is shown that Nok usually affords yields that are, in general, as good or better than those typically obtained with TPGS-750-M, and yet is far less costly.
Sonogashira couplings of aryl bromides: Room temperature, water only, no copper
Lipshutz, Bruce H.,Chung, David W.,Rich, Brian
supporting information; experimental part, p. 3793 - 3796 (2009/07/01)
(Chemical Equation Presented) Cross-coupling reactions between lipophilic terminal alkynes and aryl bromides can be catalyzed by ligated Pd, in the absence of copper, In pure water at ambient temperatures. Small amounts of the nonionic amphiphile PTS assi
