1052216-05-3Relevant academic research and scientific papers
TPGS-750-M: A second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature
Lipshutz, Bruce H.,Ghorai, Subir,Abela, Alexander R.,Moser, Ralph,Nishikata, Takashi,Duplais, Christophe,Krasovskiy, Arkady,Gaston, Ricky D.,Gadwood, Robert C.
, p. 4379 - 4391 (2011)
An environmentally benign surfactant (TPGS-750-M), a diester composed of racemic α-tocopherol, MPEG-750, and succinic acid, has been designed and readily prepared as an effective nanomicelle-forming species for general use in metal-catalyzed cross-coupling reactions in water. Several "name" reactions, including Heck, Suzuki-Miyaura, Sonogashira, and Negishi-like couplings, have been studied using this technology, as have aminations, C-H activations, and olefin metathesis reactions. Physical data in the form of DLS and cryo-TEM measurements suggest that particle size and shape are key elements in achieving high levels of conversion and, hence, good isolated yields of products. This new amphiphile will soon be commercially available.
Surfactant-Enabled Transition Metal-Catalyzed Chemistry
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, (2011/06/23)
In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.
Sonogashira couplings of aryl bromides: Room temperature, water only, no copper
Lipshutz, Bruce H.,Chung, David W.,Rich, Brian
supporting information; experimental part, p. 3793 - 3796 (2009/07/01)
(Chemical Equation Presented) Cross-coupling reactions between lipophilic terminal alkynes and aryl bromides can be catalyzed by ligated Pd, in the absence of copper, In pure water at ambient temperatures. Small amounts of the nonionic amphiphile PTS assi
