1052237-70-3Relevant academic research and scientific papers
INHIBITION AND DISPERSION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-TRIAZOLE DERIVATIVES
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Page/Page column 44, (2009/10/30)
Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum
Rogers, Steven A.,Melander, Christian
supporting information; experimental part, p. 5229 - 5231 (2009/04/11)
(Chemical Equation Presented) A team of three: 2-Aminoimidazole, triazole, and tether units together resulted in conjugates (see picture, n=4-6 for the most active compounds) that are capable of inhibiting and dispersing bacteria biofilms without inducing bacterial death. Such biofilms have been implicated in a plethora of medical problems, including infection of implanted medical devices and the mortality of cystic fibrosis patients.
