1052264-84-2

Upstream product

• 366-99-4 3-fluoro-4-methoxyaniline 
• 149507-26-6 3-fluoro-4-methoxy-phenylboronic acid 

Downstream Products

• 1234502-42-1 ethyl 2-{4-[(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methylthio]-2-methylphenoxy}acetate 
• 1629909-27-8 3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-((1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl)phthalamide 
• 1629909-36-9 3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide 
• 1268445-30-2 C₁₉H₁₈FN₃O₅ 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of 4-substituted 1,2,3-triazole-coumarin derivatives

A new series of coumarin-1,2,3-triazole conjugates with varied alkyl, phenyl and heterocycle moieties at C-4 of the triazole nucleus were synthesized using a copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated coumarin (3) or N-propargylated coumarin (6) with alkyl or aryl azides. Based on their minimal inhibitory concentrations (MICs) against selected microorganisms, six out of twenty-six compounds showed significant antibacterial activity towards Enterococcus faecalis (MIC = 12.5–50 μg/mL). Moreover, the synthesized triazoles show relatively low toxicity against human erythrocytes.

Synthesis and antitumor activity of 1-substituted 1,2,3-triazole-mollugin derivatives

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE

The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in the treatment of inter alia cancer is disclose

Synthesis of novel 1,2,3-triazole-containing pyridinepyrazole amide derivatives based on one-pot click reaction and their evaluation for potent nematicidal activity against Meloidogyne incognita

In order to find a novel, leading nematicide compound, a series of pyridinepyrazole amide derivatives containing 1,2,3-triazoles were synthesized via click chemistry in a one-pot reaction. Their structures were characterized by proton nuclear magnetic res

Synthesis and insecticidal evaluation of novel phthalic diamides containing 1,2,3-triazoles via click reaction

A series of novel phthalic diamide derivatives containing 1,2,3-triazole moiety were synthesized using one-pot click chemistry approach and characterized by 1H NMR and HRMS. The insecticidal activity against armyworm (Mythimna separata), Tetranychu scinnabarinus and cowpea aphid (Aphis craccivora) was evaluated. Compounds 4II-a and 4II-i showed 50% insecticidal activity against armyworm (Mythimna separata) at the concentration of 4 mg/L and one-third of the compounds had moderate activity against Tetranychus cinnabarinus at 500 mg/L. Copyright

Synthesis and dual PPARα/δ agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516

Ten 1,4-disubstituted 1,2,3-triazoles 2ae2j were prepared and tested for their ability to increase oleic acid oxidation in human myotubes using a high-throughput multiwell assay. Compounds 2e (2-{4-[(1- (3-fluoro-4- (trifluoromethyl)phenyl)-1H-1,2,3-triaz