105246-17-1Relevant articles and documents
Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas
Burrows, Jeremy N.,Cumming, John G.,Fillery, Shaun M.,Hamlin, Gordon A.,Hudson, Julian A.,Jackson, Ruth J.,McLaughlin, Sharon,Shaw, John S.
, p. 25 - 28 (2007/10/03)
Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N′-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor. Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl) piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl) piperidin-4-yl]-N′-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor.
