10525-14-1

Basic information

• Product Name: N-(2-hydroxypropyl)myristamide
• Synonyms: N-(2-hydroxypropyl)myristamide;MYRISTAMIDE MIPA;Tetradecanamide, N-(2-hydroxypropyl)-;N-(2-Hydroxypropyl)myristic acid amide;N-(2-Hydroxypropyl)myristinamide;N-(2-Hydroxypropyl)tetradecanamide;Einecs 234-077-9;Monoisopropanolamine myristic acid amide
• CAS NO: 10525-14-1
• Molecular Formula: C₁₇H₃₅NO₂
• Molecular Weight: 285.4653
• EINECS: 234-077-9
• Mol File: 10525-14-1.mol

Chemical Properties

• Boiling Point: 444.1°Cat760mmHg
• Flash Point: 222.4°C
• Appearance: /
• Density: 0.912g/cm³
• Vapor Pressure: 9.44E-10mmHg at 25°C
• Refractive Index: 1.461
• CAS DataBase Reference: N-(2-hydroxypropyl)myristamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxypropyl)myristamide(10525-14-1)
• EPA Substance Registry System: N-(2-hydroxypropyl)myristamide(10525-14-1)

Safety Data

• Hazardous Substances Data: 10525-14-1(Hazardous Substances Data)

Usage

Uses

Used in Cosmetic and Personal Care Products:
N-(2-hydroxypropyl)myristamide is used as an emulsifying and thickening agent for its ability to stabilize and improve the texture of formulations such as lotions, creams, and hair care products. It enhances the consistency and stability of these products, ensuring a smooth and pleasant application experience.
Used in Industrial Applications:
In industrial settings, N-(2-hydroxypropyl)myristamide is used as a surfactant to reduce the surface tension of liquids, improving their ability to mix with other substances. This property is valuable in various manufacturing processes where the blending of different components is required.
Safety:
N-(2-hydroxypropyl)myristamide is considered to be safe for use in cosmetics and personal care products when used in accordance with regulations and guidelines, ensuring the well-being of consumers and the effectiveness of the products in which it is incorporated.

InChI:InChI=1/C17H35NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-17(20)18-15-16(2)19/h16,19H,3-15H2,1-2H3,(H,18,20)

Upstream product

• 544-63-8 n-tetradecanoic acid 
• 78-96-6 3-amino-2-propanol 

Relevant articles and documents

The effect of substrate structure on the chemoselectivity of Candida antarctica lipase B-catalyzed acylation of amino-alcohols

The selective acylation of multifunctional compounds exhibiting both alcohol and amino groups gives interesting products with many applications in food, cosmetic and pharmaceutical industries, but it is real challenge. The current work describes the different behavior shown by Candida antarctica lipase B (Novozym 435) when catalyzing the O-acylation and N-acylation of bifunctional acyl acceptors. The acylation of three amino-alcohols (alaninol, 4-amino-1-pentanol and 6-amino-1-hexanol) was studied using myristic acid as an acyl donor. To achieve this, a structure-reactivity study was performed in tert-amyl alcohol as a solvent, comparing the three amino-alcohols as acyl acceptors and a series of structurally related amines, namely (R)-sec-butylamine, 1-methoxy-2-propylamine and 1,2-diaminopropane. These substrates were designed to investigate the effect of the group located in β-position of the amino group on the acyl acceptor: the more nucleophilic the group, the more the apparent maximal velocity (Vmax,app) of N-acylation increases. Moreover, the crucial role of the carbon chain length between the alcohol and amino groups on the chemoselectivity was also demonstrated. The chemoselectivity for the N-acylation was improved when the carbon chain included two carbons (alaninol) whereas the chemoselectivity for the O-acylation was improved when the carbon chain included four carbons or more (4-amino-1-pentanol and 6-amino-1-hexanol). These results provided new insights for the selective synthesis of amides or esters produced from the acylation of bifunctional substrates.