1052670-08-2Relevant articles and documents
A microreactor with phase-change microvalves for batch chemical synthesis at high temperatures and pressures
Ma, Xiaoxiao,Tseng, Wei-Yu,Eddings, Mark,Keng, Pei Yuin,Van Dam, R. Michael
, p. 280 - 285 (2014)
We present a simple microreactor with dimethyl sulfoxide (DMSO) phase-change valves suitable for performing batch organic chemistry under high temperature and pressure conditions. As a proof of principle, we demonstrate a radiofluorination reaction import
Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression
Pillarsetty, Nagavarakishore,Cai, Shangde,Ageyeva, Lyudmila,Finn, Ronald D.,Blasberg, Ronald G.
, p. 5377 - 5381 (2006)
Synthesis of three novel 2′-deoxy-2′-[18F]fluoro-1- β-D-arabinofuranosyluracil derivatives [18F]FPAU, [ 18F]-FBrVAU, and [18F]FTMAU is reported. The compounds were synthesized by coupling of 1-bromo-2-deoxy-2-fluoro sugars with corresponding silylated uracil derivatives. In vitro cell uptake indicated that all three compounds are taken up selectively in RG2TK+ cells with negligible uptake in RG2 cells. The results indicate that [18F]FBrVAU and [ 18F]FTMAU have better uptake profiles in comparison to [ 18F]FPAU and have potential as PET probes for imaging HSV1-tk gene expression.
AN AUTOMATED, MULTI-POT HIGH-PRESSURE RADIO-SYNTHESIZER FOR PRODUCTION OF PET TRACERS
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Sheet 12, (2016/10/17)
An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the