1052686-67-5

Basic information

• Product Name: 2-MethylpyriMidine-5-boronic Acid Pinacol Ester
• Synonyms: 2-MethylpyriMidine-5-boronic Acid Pinacol Ester;1H-BenziMidazole, 2-Methyl-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;PyriMidine, 2-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;2-MethylpyriMidin-5-ylboronic acid pinacol ester;2-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine
• CAS NO: 1052686-67-5
• Molecular Formula: C₁₁H₁₇BN₂O₂
• Molecular Weight: 258.12386
• EINECS: 1592732-453-0
• Mol File: 1052686-67-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 310.6±15.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.63±0.22(Predicted)
• CAS DataBase Reference: 2-MethylpyriMidine-5-boronic Acid Pinacol Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MethylpyriMidine-5-boronic Acid Pinacol Ester(1052686-67-5)
• EPA Substance Registry System: 2-MethylpyriMidine-5-boronic Acid Pinacol Ester(1052686-67-5)

Safety Data

• Hazardous Substances Data: 1052686-67-5(Hazardous Substances Data)

Usage

General Description

2-Methylpyrimidine-5-boronic Acid Pinacol Ester is a specialty chemical compound primarily used in scientific research and reactions. Its specific function or application can often depend on the experiment or reaction it is being utilized in. Chemically, this substance features a boronic acid pinacol ester functional group and a 2-methylpyrimidine moiety. As a boronic ester, it has the property of reacting with certain compounds to form boronates, which allows its use in various couplings, additions or substitutions in organic chemistry. The chemical's properties can make it suitable for usage in medicinal and pharmaceutical chemistry or research, particularly in the synthesis of some biologically active molecules or compounds. However, information on its safety and handling should always be sought and reviewed before usage.

Upstream product

• 5053-43-0 2-methylpyrimidine 
• 73183-34-3 bis(pinacol)diborane 
• 7752-78-5 5-bromo-2-methylpyrimidine 

Downstream Products

• 1610346-16-1 4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-amine 
• 1903768-17-1 (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide 

Relevant articles and documents

PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES

The present invention relates to a class of TrkA inhibitors and an application thereof in the preparation of a drug for the treatment of diseases associated with TrkA. The present invention specifically discloses compounds represented by formula (I) and f

MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce excessive activation of complement.

ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.