1052714-37-0

Basic information

• Product Name: 5-amino-2-(2-fluorophenyl)pyrimidine-4-carboxylic acid
• Synonyms: 5-amino-2-(2-fluorophenyl)pyrimidine-4-carboxylic acid
• CAS NO: 1052714-37-0
• Molecular Weight: 233.202
• Mol File: 1052714-37-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-amino-2-(2-fluorophenyl)pyrimidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-2-(2-fluorophenyl)pyrimidine-4-carboxylic acid(1052714-37-0)
• EPA Substance Registry System: 5-amino-2-(2-fluorophenyl)pyrimidine-4-carboxylic acid(1052714-37-0)

Safety Data

• Hazardous Substances Data: 1052714-37-0(Hazardous Substances Data)

Upstream product

• 488-11-9 mucobromic acid 

Downstream Products

• 1052708-04-9 5-amino-2-(2-fluoro-phenyl)-pyrimidine-4-carboxylic acid [4-(6-amino-2-methyl-pyrimidin-4-yl)-pyridin-3-yl]-amide 

Relevant articles and documents

Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold

The Pim proteins (1, 2 and 3) are serine/threonine kinases that have been found to be upregulated in many hematological malignancies and solid tumors. As a result of overlapping functions among the three isoforms, inhibition of all three Pim kinases has become an attractive strategy for cancer therapy. Herein we describe our efforts in identifying potent pan-PIM inhibitors that are derived from our previously reported pyridyl carboxamide scaffold as part of a medicinal chemistry strategy to address metabolic stability.