105300-90-1Relevant articles and documents
Development of a new traceless aniline linker for solid-phase synthesis of azomethines. Application to parallel synthesis of a rod-shaped liquid crystalline library
Hioki, Hideaki,Fukutaka, Mizuki,Takahashi, Hideki,Kubo, Miwa,Matsushita, Kimihito,Kodama, Mitsuaki,Kubo, Kanji,Ideta, Keiko,Mori, Akira
, p. 10643 - 10651 (2005)
A new traceless linker was developed to synthesize a library of 42 compounds possessing an azomethine linkage using combinatorial solid-phase parallel synthesis. The loading of the substrates on a solid support and cleavage from the solid support were performed by an imine synthesis and by imine-exchanged process under mild conditions, respectively. Thioesters with a hydroxy group on the central core exhibited liquid crystalline properties with the widest transition temperatures in the library.
DIARYLHYDANTOIN COMPOUNDS
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Page/Page column 5, (2009/05/28)
The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
Antihypertensive dihydropyridine compositions, optical isomers and intermediates
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, (2008/06/13)
Compositions containing dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: STR1 or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer from 0 to 8; Y is --O--, --NH--, --NR2 --, --S--, --S(O)--, --S(O)2 --, or a bond; R1 and R2 are each independently A1, A2, A3 or A4 where A1 is --(CH2)m (CHOH)p CH2 OH; A2 is --(CH2)q CH(3-r) [(CH2)s OH]r ; A3 is --(CH2)q CH(3-r) [(CH2)p COOR3 ]r ; and A4 is --(CH2)m COOR3 ; where m is an integer from 1 to 8; p is an integer from 0 to 4; q is an integer from 0 to 8; r is 2 or 3; s is an integer from 1 to 4; and R3 is H or alkyl of 1 to 18 carbon atoms; R4 is --NO2, --CF3, or halo; and R5 is lower alkyl or --CH2 CH2 OCH3. Also disclosed are optical isomers of the above compounds, as well as intermediates in the preparation of these final products.