1053244-62-4

Upstream product

• 51549-37-2 N⁴-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine 
• 93134-40-8 N⁴-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine 
• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 232588-73-7 N⁴-benzoyl-1-<3-O-(tert-butyldimethylsilyl)-2-deoxy-4α-hydroxymethyl-β-D-ribo-pentofuranosyl>cytosine 
• 156100-66-2 N-{1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3-oxo-propyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 232588-74-8 N-{1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 232588-83-9 N⁴-benzoyl-1-<3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-4α-iodomethyl-β-D-ribo-pentofuranosyl>cytosine 
• 232588-75-9 N⁴-benzoyl-1-<3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-4α-hydroxymethyl-β-D-ribo-pentofuranosyl>cytosine 
• 232588-76-0 N⁴-benzoyl-1-<3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-4α-formyl-β-D-ribo-pentofuranosyl>cytosine 
• 232588-84-0 N⁴-benzoyl-1-<3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-4α-methyl-β-D-ribo-pentofuranosyl>cytosine 
• 232588-79-3 1-<3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-4α-ethynyl-β-D-ribo-pentofuranosyl>cytosine 
• 232588-87-3 1-<3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-4α-methyl-β-D-ribo-pentofuranosyl>cytosine 
• 156100-69-5 (E)-3-[(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'α-C-branched-chain sugar pyrimidine nucleosides

A series of 4'α-C-branched-chain pyrimidine nucleosides was synthesized from 2'-deoxycytidine or uridine. In the 2'-deoxycytidine series, the substituent at the 4'α-position affected cytotoxicity against L1210 mouse leukemic cells in vitro in the order Me (23) > CN (22)> C≡CH (21) > CH=CH2 (19) > Et (24) > CH=CHCl (20). However, uridine and cytidine derivatives with ethynyl and cyano groups at the 4'α-position did not show any cytotoxicity. The antiviral activities of these nucleosides against HSV-1, HSV-2, and HIV- 1 in vitro were also examined. Compounds 22 and 23 showed antiviral activities against HSV-1 and HSV-2 without showing significant toxicity to the host cells (MRC-5 cells). Although almost all of the nucleosides showed anti-HIV-1 activities, they were also cytotoxic to the host cells (MT-4).

The synthesis of modified achiral internucleoside linkages: -NHCH2CH2-linked oligonucleosides

A method for the synthesis of oligonucleosides uniformly linked by the NHCH2CH2 moiety is described. Syntheses of heterodimers and a thymidylate trimer along with relevant T and nuclease resistance data are described.