1053255-23-4Relevant articles and documents
Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure- activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues
De Lucca, George V.,Kim, Ui T.,Liang, Jing,Cordova, Beverly,Klabe, Ronald M.,Garber, Sena,Bacheler, Lee T.,Lam, Gilbert N.,Wright, Matthew R.,Logue, Kelly A.,Erickson-Viitanen, Susan,Ko, Soo S.,Trainor, George L.
, p. 2411 - 2423 (2007/10/03)
Using the structural information gathered from the X-ray structures of various cyclic urea/HIVPR complexes, we designed and synthesized many nonsymmetrical P2/P2'-substituted cyclic urea analogues. Our efforts concentrated on using an indazole as one of t