1053269-75-2Relevant academic research and scientific papers
Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates
Prechter, Agnes,Groeger, Harald,Heinrich, Markus R.
supporting information; experimental part, p. 3384 - 3387 (2012/06/01)
The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated using benzylamine as amine component. The products obtained from this biotransformation in high enantiomeric purity can serve as valuable precursors for various amino alcohols, as exemplified by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine.
Chiral azo compounds: Enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter
Dietz, Friedrich R.,Prechter, Agnes,Gr?ger, Harald,Heinrich, Markus R.
supporting information; experimental part, p. 655 - 657 (2011/03/21)
Taking advantage of radical carboaminations producing azo compounds, a new chemo-enzymatic approach to enantiomerically enriched azo alcohols, β-amino alcohols and non-natural (aromatic) amino acids with a quaternary stereocenter is reported.
Radical carbodiazenylation - A convenient and effective method to achieve carboamination of non-activated olefins
Blank, Olga,Wetzel, Alexander,Ullrich, Daniela,Heinrich, Markus R.
experimental part, p. 3179 - 3189 (2009/05/11)
The regioselective addition of aryl and aryldiazenyl substituents to olefinic substrates can be described as carbodiazenylation. In this report we present our final results relating to this unique type of radical functionalization reaction, which has now
