105337-42-6

Basic information

• Product Name: AKOS BC-2521
• Synonyms: 5-ISOPROPYL-4-METHOXY-2-METHYLBENZALDEHYDE;5-isopropyl-4-methoxy-2-methylbenzaldehyde(SALTDATA: FREE);4-methoxy-2-methyl-5-propan-2-ylbenzaldehyde;4-methoxy-2-methyl-5-propan-2-yl-benzaldehyde;ZINC02597446;ASISCHEM R35270;CHEMBRDG-BB 6531894;AKOS BC-2521
• CAS NO: 105337-42-6
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• Mol File: 105337-42-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 307°C at 760 mmHg
• Flash Point: 131.4°C
• Appearance: /
• Density: 1.004g/cm³
• Vapor Pressure: 0.000745mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: AKOS BC-2521(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BC-2521(105337-42-6)
• EPA Substance Registry System: AKOS BC-2521(105337-42-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 105337-42-6(Hazardous Substances Data)

Usage

General Description

AKOS BC-2521 is a chemical compound that has a molecular formula of C10H14N2O2S and a molecular weight of 230.3 g/mol. It is a pale yellow solid that is mainly used in pharmaceutical research and as an intermediate in organic synthesis. The compound is considered to have low toxicity, with no known adverse effects associated with its use. AKOS BC-2521 has applications in the development of pharmaceuticals, agrochemicals, and other specialty chemicals, making it a valuable tool for researchers in various fields.

InChI:InChI=1/C12H16O2/c1-8(2)11-6-10(7-13)9(3)5-12(11)14-4/h5-8H,1-4H3

Upstream product

• 854259-61-3 bis-(5-isopropyl-4-methoxy-2-methyl-benzyl)-ether 
• 1076-56-8 Thymol methyl ether 
• 68-12-2 N,N-dimethyl-formamide 
• 4395-91-9 4-formylthymol 
• 77-78-1 dimethyl sulfate 
• 168783-13-9 5-isopropyl-4-methoxy-2-methyl-benzyl alcohol 
• 89-83-8 thymol 
• 74-88-4 methyl iodide 

Downstream Products

• 105401-55-6 5-isopropyl-4-methoxy-2-methyl-benzoic acid 
• 102447-50-7 (E)-3-(5-isopropyl-4-methoxy-2-methylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 102553-20-8 5-isopropyl-4-methoxy-2-methyl-trans-chalcone 
• 100451-10-3 5-isopropyl-4-methoxy-2-methyl-benzaldehyde-semicarbazone 
• 78347-89-4 methyl thymol 
• 119078-13-6 (2-isopropyl-4,5-dimethyl-phenoxy)-acetic acid-(5-isopropyl-4-methoxy-2-methyl-benzylidenehydrazide) 
• 116602-49-4 2-isopropyl-4-(5-isopropyl-4-methoxy-2-methyl-benzylidenamino)-5-methyl-phenol 
• 102953-56-0 5,5'-diisopropyl-4,4'-dimethoxy-2,2'-dimethyl-trans-chalcone 
• 114446-70-7 7-isopropyl-2-((Z)-5-isopropyl-4-methoxy-2-methyl-benzylidene)-4-methyl-benzofuran-3-one 
• 113013-28-8 1-(2,5-dimethyl-[3]furyl)-3t-(5-isopropyl-4-methoxy-2-methyl-phenyl)-propenone 
• 110061-48-8 (E)-3-(5-isopropyl-4-methoxy-2-methylphenyl)-1-(thiophen-2-yl)prop-2-en-1-one 
• 112948-37-5 2-((Z)-4-hydroxy-5-isopropyl-2-methyl-benzylidene)-7-isopropyl-4-methyl-benzofuran-3-one 
• 116083-38-6 6,6'-diisopropyl-3,4,3',4'-tetramethyl-2,2'-methanediyl-di-phenol 
• 109105-26-2 (2-isopropyl-4,5-dimethyl-phenoxy)-acetic acid hydrazide 

Relevant articles and documents

Synthesis of thymol-based pyrazolines: An effort to perceive novel potent-antimalarials

A series of thymol based substituted pyrazolines and chalcones was synthesized and evaluated for antimalarial activity, using in-vitro and in-vivo malaria models. All the target compounds (5a-k and 6a-j)were found to be active against human malaria parasite strain Plasmodium falciparum NF54. Among all, compounds 5e and 5f of chalcone series and 6c and 6f of pyrazoline series exhibited prominent antimalarial activity with IC50 less than 3 and 2 μM respectively, while other pyrazolines also significantly inhibited the P. falciparum with IC50 less than 10 μM. The designed pharmacophores were found to be effective against P. falciparum. Compound 6f was found to be able to retard malaria progression in mice. This was evident through decreased parasitemia, increased mean survival time and hemoglobin content in the treated animals. Moreover, 6f was observed as an inhibitor of heme polymerization pathway of the malaria parasite. It also inhibited free heme degradation, which could be possibly responsible for higher reactive oxygen species (ROS)in parasite, thus inhibiting the rapid proliferation of the parasite. In addition to this, compound 6f was found to be non-toxic with a good selectivity index. Based on these observations, the compound 6f could be taken up for further antimalarial lead optimization studies.