1053418-57-7Relevant articles and documents
Novel insight in structure-activity relationship and bioanalysis of P-glycoprotein targeting highly potent tetrakishydroxymethyl substituted 3,9-diazatetraasteranes
Coburger, Claudius,Wollmann, J?rg,Baumert, Christiane,Krug, Martin,Molnár, Josef,Lage, Hermann,Hilgeroth, Andreas
, p. 5871 - 5874 (2008)
Novel 3,9-diazatetraasteranes have been synthesized with varied aromatic substitution patterns and evaluated as P-glycoprotein (P-gp) inhibitors. Structure-activity relationships (SAR) are discussed in relation to determined physicochemical properties. Th