10535-63-4

Upstream product

• 1450994-70-3 (3-bromo-2H-chromen-7-yloxy)(tert-butyl)dimethylsilane 
• 151884-07-0 2',4'-dihydroxy-3-chloropropiophenone 
• 124887-46-3 3-bromo-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one 
• 76240-27-2 7-hydroxy-2,3-dihydro-4H-chromen-4-one 
• 108-46-3 recorcinol 
• 10499-16-8 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran 
• 10499-10-2 7-acetoxy-3-(4-methoxy-phenyl)-2H-chromene 

Relevant academic research and scientific papers

Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist

Total synthesis of eryvarin H and a biological investigation of its analogues as a potential inverse agonist of ERRγ are described here. Among the 13 analogues prepared by the modular synthetic route, eryvarin H and compound 12 showed meaningful ERRγ inverse agonistic activities along with moderate selectivity over ERα and other nuclear receptors in the cell-based reporter gene assay.

Processes for Preparing Isoflavonoids using 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran as a Starting Material

Disclosed herein are processes for the preparation of isoflavonoids, in particular haginin E, equol, daidzein, formononetin and the like, in which 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran is used as a common starting material.

Synthesis of haginin E, equol, daidzein, and formononetin from resorcinol via an isoflavene intermediate

New syntheses of haginin E, equol, daidzein, and formononetin are described in this Letter. Through a sequence of a Wittig reaction, O-alkylation, and another Wittig reaction, 4-benzyloxysalicylaldehyde, which was prepared from resorcinol in two steps, was converted into the desired diene in one pot. Subsequently, the prepared diene was subjected to ring-closing metathesis using Grubbs' catalyst (II) to construct the desired isoflavene intermediate. Using the prepared isoflavene, certain isoflavonoids such as haginin E, equol, daidzein, formononetin, and other related compounds were derived smoothly and in good overall yields.

Production of isoflavone derivatives

Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.