Basic information

Product Name: [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone
Synonyms: [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone;1-(4-Amino-6-hydroxy-7-methoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine;Terazosin EP Impurity G;1-(4-Amino-6-hydroxy-7-methoxyquinazolin-2-yl)-4-(((2RS)-tetrahydrofuran-2-yl)carbonyl)piperazine
CAS NO:105356-89-6
Molecular Formula: C18H23N5O4
Molecular Weight: 373.40632
EINECS: N/A
Product Categories: Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File: 105356-89-6.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 697.5±65.0 °C(Predicted)
Flash Point: N/A
Appearance: /
Density: 1.408±0.06 g/cm3(Predicted)
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
PKA: 9.02±0.40(Predicted)
CAS DataBase Reference: [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone(CAS DataBase Reference)
NIST Chemistry Reference: [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone(105356-89-6)
EPA Substance Registry System: [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone(105356-89-6)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 105356-89-6(Hazardous Substances Data)

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Usage
SDS
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105356-89-6 Usage

Uses

Used in Pharmaceutical Industry:
[4-(4-Amino-6-hydroxy-7-methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)methanone is used as an impurity in Terazosin, an α-1-adrenergic blocker. Its presence in the pharmaceutical compound is significant as it can potentially affect the drug's efficacy, safety, and quality. As a result, monitoring and controlling the levels of this impurity in Terazosin is crucial for ensuring the drug meets regulatory standards and maintains its therapeutic benefits.
Additionally, due to its structural similarity to Prazosin, [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone may also be of interest for research purposes in the development of new α-1-adrenergic blockers or for understanding the mechanisms of action of existing drugs in this class. Further studies may reveal potential applications in the treatment of conditions such as hypertension, benign prostatic hyperplasia, and other related disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 105356-89-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,3,5 and 6 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 105356-89:
(8*1)+(7*0)+(6*5)+(5*3)+(4*5)+(3*6)+(2*8)+(1*9)=116
116 % 10 = 6
So 105356-89-6 is a valid CAS Registry Number.

105356-89-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	[4-(4-amino-6-hydroxy-7-methoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone

1.2 Other means of identification

Product number	-
Other names	UNII-3O886C86WZ

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105356-89-6 SDS

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