105359-79-3

Upstream product

• 4210-32-6 4-tert-butyl benzonitrile 
• 141-43-5 ethanolamine 
• 877-65-6 p-tert-butylbenzyl alcohol 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 106854-96-0 4-tert-Butyl-N-(2-hydroxy-ethyl)-benzamide 

Downstream Products

• 126773-85-1 5-Bromo-2-(4-tert-butylphenyl)oxazole 
• 126773-86-2 2-(4-(tert-butyl)phenyl)oxazole 
• 126773-88-4 C₁₃H₁₄⁽²⁾HNO 

Relevant academic research and scientific papers

Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones

The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.

A simple synthesis of 2-substituted oxazolines and oxazines

β-Aminoalcohols react with carboxylic acids in the presence of a zeolite, Ersorb-4, resulting in the formation of oxazoline derivatives in good yields. Similarly, 3-aminopropanol and benzoic acid gave the corresponding 2-phenyloxazine.

Synthesis of 2-Aryl- and 5-Alkyl-2-aryloxazoles from 2-Aryl-5-bromooxazoles

2-Aryloxazoles, their 5-deuterio derivatives, and 5-alkyl-2-aryloxazoles are prepared in good yields from 2-aryl-5-bromooxazoles via halogen/metal exchange with butyllithium followed by treatment with water, methanol-O-d, or alkyl halides, respectively.

A New Simple and Mild Synthesis of 2-Substituted 2-Oxazolines

N-Acylated β-aminoalcohols were converted to 2-oxazolines under very mild conditions employing commonly used phosphorylating reagents.