1053747-01-5

Basic information

• Product Name: (4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-cyclohexylmethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-ylidene-cyanamide
• Synonyms: (4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-cyclohexylmethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-ylidene-cyanamide
• CAS NO: 1053747-01-5
• Molecular Weight: 803.289
• Mol File: 1053747-01-5.mol

Chemical Properties

• CAS DataBase Reference: (4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-cyclohexylmethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-ylidene-cyanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-cyclohexylmethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-ylidene-cyanamide(1053747-01-5)
• EPA Substance Registry System: (4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-cyclohexylmethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-ylidene-cyanamide(1053747-01-5)

Safety Data

• Hazardous Substances Data: 1053747-01-5(Hazardous Substances Data)

Upstream product

• 153181-18-1 dibenzyl ((2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate 
• 153181-20-5 (2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine 
• 153223-10-0 (2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 153214-43-8 (4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-ylidene-cyanamide 

Relevant articles and documents

Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: Synthesis, structure - Activity relationships, and X-ray crystal structure studies

Comparison of the high-resolution X-ray structures of the native HIV-1 protease and its complexes with the inhibitors suggested that the enzyme flaps are flexible. The movement at the tip of the flaps could be as large as 7 A. On the basis of this observa