1053805-76-7

Basic information

• Product Name: 2-{(3R)-3-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentyl}-1,3-thiazole-4-carboxylic acid
• Synonyms: 2-{(3R)-3-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentyl}-1,3-thiazole-4-carboxylic acid
• CAS NO: 1053805-76-7
• Molecular Weight: 342.459
• Mol File: 1053805-76-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{(3R)-3-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentyl}-1,3-thiazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{(3R)-3-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentyl}-1,3-thiazole-4-carboxylic acid(1053805-76-7)
• EPA Substance Registry System: 2-{(3R)-3-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentyl}-1,3-thiazole-4-carboxylic acid(1053805-76-7)

Safety Data

• Hazardous Substances Data: 1053805-76-7(Hazardous Substances Data)

Upstream product

• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 

Downstream Products

• 1174764-12-5 (2S,4R)-2-methyl-4-[({2-[(3R)-4-methyl-3-{methyl[(2S,3S)-3-methyl-2-({[(2R)-1-methylpiperidin-2-yl]carbonyl}amino)pentanoyl]amino}pentyl]-1,3-thiazol-4-yl}carbonyl)amino]-5-phenylpentanoic acid 
• 1219930-75-2 methyl (2S,4R)-2-methyl-4-[({2-[(3R)-4-methyl-3-{methyl[(2S,3S)-3-methyl-2-({[(2R)-1-methylpiperidin-2-yl]carbonyl}amino)pentanoyl]amino}pentyl]-1,3-thiazol-4-yl}carbonyl)amino]-5-phenylpentanoate 

Relevant articles and documents

Design, synthesis, and antitumor activity evaluation of pretubulysin analogs

Pretubulysin, a biosynthetic precursor of the tubulysins, shows potent biological activity in a variety of tumor cell lines. Although there are several total synthesis routes to tubulysin and pretubulysin reported, the commercialization still has been hampered due to the complexity of the structure. To find structurally simpler pretubulysin analogs, a series of 2-(3-(methylamino)propyl)thiazole-4-carboxamides are designed and synthesized, and their anticancer activities are screened using MCF-7 (breast cancer), and NCI-H157 (lung cancer) cell lines. Taxol (IC50?=?0.01?μM) and pretubulysin are used as the control. Compounds 8c (IC50?=?0.05?μM, MCF-7; 0.09?μM, NCI-H157) and 8h (IC50?=?0.01?μM, MCF-7; 0.02?μM, NCI-H157) exhibited certain antitumor activities comparable to those of Taxol. The urea analogs of pretubulysin might represent a promising scaffold for the further development of novel antitumor drugs.