1054-88-2

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Basic information

Product Name: SPIROXATRINE
Synonyms: SPIROXATRINE;R 5188;(+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE;8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE;SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5;R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one;Spiroxatrine (R 5188);8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CAS NO:1054-88-2
Molecular Formula: C22H25N3O3
Molecular Weight: 379.45
EINECS: N/A
Product Categories: Serotonin receptor
Mol File: 1054-88-2.mol
Article Data: 0

Chemical Properties

Melting Point: 215.8-218.0 °C
Boiling Point: 602.8°Cat760mmHg
Flash Point: 318.4°C
Appearance: white/powder
Density: 1.32g/cm³
Vapor Pressure: 1.74E-14mmHg at 25°C
Refractive Index: 1.665
Storage Temp.: Store at RT
Solubility: 0.1 M HCl: moderately soluble
PKA: 15.03±0.20(Predicted)
CAS DataBase Reference: SPIROXATRINE(CAS DataBase Reference)
NIST Chemistry Reference: SPIROXATRINE(1054-88-2)
EPA Substance Registry System: SPIROXATRINE(1054-88-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany: 3
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1054-88-2(Hazardous Substances Data)

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Pharmaceutical Grade CAS 1054-88-2 with competitive price
Cas No: 1054-88-2
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Zhuozhou Wenxi import and Export Co., Ltd
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1,3,8-Triazaspiro[4.5]decan-4-one,8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-
Cas No: 1054-88-2
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Hangzhou J&H Chemical Co., Ltd.
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SPIROXATRINE
Cas No: 1054-88-2
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Shanghai Run-Biotech Co., Ltd.
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Spiroxatrine;8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)Methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Cas No: 1054-88-2
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Wuxi Morality Chemical Co., Ltd
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8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Cas No: 1054-88-2
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NovaChemistry
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1,3,8-Triazaspiro[4.5]decan-4-one,8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-
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AXXORA, LLC
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1054-88-2 Usage

Uses

Spiroxatrine (R 5188) is a SR-1A antagonist.

Biological Activity

5-HT 1A antagonist. More active and selective than spiperone. Also a very potent α 2C adrenergic receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 1054-88-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,5 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1054-88:
(6*1)+(5*0)+(4*5)+(3*4)+(2*8)+(1*8)=62
62 % 10 = 2
So 1054-88-2 is a valid CAS Registry Number.

InChI:InChI=1/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)

1054-88-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

1.2 Other means of identification

Product number	-
Other names	Spiroxatrine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1054-88-2 SDS

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1054-88-2Related news

SPIROXATRINE (cas 1054-88-2) augments fluoxetine-induced reduction of ethanol intake by the P line of rats07/25/2019

The present study was undertaken to determine if spiroxatrine, a reported 5-HT1A antagonist, could block the attenuating effects of fluoxetine (a 5-HT uptake inhibitor) on voluntary ethanol intake by the selectively bred alcohol-preferring P line of rats. Fluoxetine (10 mg/kg, IP) significantly ...detailed

α1-adrenoceptor blocking properties of SPIROXATRINE (cas 1054-88-2) in rat aorta07/24/2019

This preliminary study has analyzed the potential ability of the 5-HT1A ligand spiroxatrine to interact with vascular α1-adrenoceptors. Norepinephrine and the selective α1-adrenoceptor agonist, methoxamine, elicited concentration-dependent contractions of rat aortic rings. In contrast, (±)-sp...detailed

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