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8-(4-oxo-4-phenylbutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a complex organic compound characterized by its unique molecular structure. It features a spiro ring system, which consists of a triazaspirodecanone core fused with a phenyl group. The compound has a 4-oxo-4-phenylbutyl side chain attached to the spiro ring system, contributing to its overall structure and properties. This chemical is primarily of interest in the field of organic chemistry, where it may be studied for its potential applications in the synthesis of pharmaceuticals, agrochemicals, or other specialty chemicals. Its specific reactivity, stability, and potential interactions with biological systems are areas that could be explored in further research.

1054-89-3

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1054-89-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1054-89-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,5 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1054-89:
(6*1)+(5*0)+(4*5)+(3*4)+(2*8)+(1*9)=63
63 % 10 = 3
So 1054-89-3 is a valid CAS Registry Number.

1054-89-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-(4-oxo-4-phenylbutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

1.2 Other means of identification

Product number -
Other names 1,3,8-Triazaspiro(4.5)decan-4-one,8-(3-benzoylpropyl)-1-phenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1054-89-3 SDS

1054-89-3Downstream Products

1054-89-3Relevant academic research and scientific papers

Binding of spiperone analogs at 5-HT(2A) serotonin receptors

Khorana, Nantaka,Bondarev, Mikhail,Dukat, Malgorzata,Herrick-Davis, Katharine,Egan, Christina,DuPre, Ann,Smith, Carol,Teitler, Milt,Glennon, Richard A.

, p. 657 - 667 (2007/10/03)

Although spiperone displays good selectivity for 5-HT(2A) versus 5- HT(2C) serotonin receptors, it suffers from high affinity for 5-HT(1A) and dopamine D2 receptors. In order to determine a) the contribution of various structural features to 5-HT(2A) affinity, and b) if spiperone binds in a manner comparable to that of the 5-HT2 antagonist ketanserin, several abbreviated analogs of spiperone were prepared and examined. Removal of the spiperone fluoro group enhances 5-HT(2A) affinity several-fold, but does not improve its selectivity. The butyrophenone carbonyl group is not a major contributor to binding, but removal of the triazaspirodecanone carbonyl group reduces affinity at all receptor populations by about 100-fold. For a series of spiperone analogs, a three- to four-atom chain seems optimal for 5-HT(2A) affinity. On the basis of the structure-activity findings, it is concluded that ketanserin and spiperone likely bind at 5-HT(2A) receptors in a dissimilar manner.

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