105417-10-5

Basic information

• Product Name: 4-chloro-2-hydroxy-N-methylbenzamide
• Synonyms: 4-chloro-2-hydroxy-N-methylbenzamide
• CAS NO: 105417-10-5
• Molecular Weight: 185.61
• Mol File: 105417-10-5.mol

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-hydroxy-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-hydroxy-N-methylbenzamide(105417-10-5)
• EPA Substance Registry System: 4-chloro-2-hydroxy-N-methylbenzamide(105417-10-5)

Safety Data

• Hazardous Substances Data: 105417-10-5(Hazardous Substances Data)

Upstream product

• 1613319-97-3 5-chloro-2-(methylcarbamoyl)phenyl 4-chlorobenzoate 
• 108-43-0 3-monochlorophenol 
• 624-83-9 methyl isocyanate 

Relevant articles and documents

Ortho-benzoxylation of N-alkyl benzamides with aromatic acids catalyzed by ruthenium(II) complex

A highly regioselective ortho-benzoxylation of N-alkyl benzamides with aromatic acids in the presence of [{RuCl2(p-cymene)}2], AgSbF6, and (NH4)2S2O8 in 1,2-dichloroethane at 100°C for 24 h affording ortho-benzoxylated N-alkyl benzamides by C-H bond activation is described. Further, Ru-catalyzed alkenylation is done at the ortho C-H bond of benzoxylated N-alkyl benzamides with alkenes in water solvent. Subsequently, the benzoxyl moiety of N-alkyl benzamides was converted into a hydroxyl group in the presence of base or acid. A possible reaction mechanism was proposed to account for the present coupling reaction. C-H bond activation: A highly regioselective ortho-benzoxylation of benzamides with substituted benzoic acids in the presence of a ruthenium catalyst is described. Further, Ru-catalyzed alkenylation is carried out at the ortho C-H bond of benzoxylated N-alkyl benzamides with alkenes in water solvent. Subsequently, the benzoxyl moiety of N-alkyl benzamides was converted into the hydroxyl group in the presence of base or acid (see scheme).

BORON TRICHLORIDE CATALYZED ORTHO CARBONYLATION OF PHENOLS: SYNTHESIS OF 2-HYDROXY-ARYL-CARBOXYAMIDES AND -KETONES.

In the presence of equimolar quantity of BCl3, phenols 1 react with isocyanates and acyl chlorides to give, usually with good-excellent yields, 2-hydroxy-aryl-carboxy-amides 2 and 2-hydroxy-aryl-ketones 3 respectively.A distinctive behaviour of BCl3 in comparison with other Lewis acids is observed.