105426-71-9

Upstream product

• 468-68-8 (-)-drimenol 

Downstream Products

• 603961-41-7 (11S,13S)-15-(4-methoxyphenoxy)labd-7-ene-11,13-diol 
• 468-68-8 (-)-drimenol 
• 111319-84-7 drimenic acid 
• 1619983-97-9 N-((2R,3S,4S,4aR)-4-(2-(4-fluorobenzamido)ethyl)-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl)-4-methylpiperazine-1-carboxamide 
• 1619983-96-8 4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide 
• 1619983-92-4 N-((2R,3S,4S,4aS)-4-((4-fluorobenzamido)methyl)-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl)-4-methylpiperazine-1-carboxamide 
• 1619983-91-3 4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide 
• 1619984-57-4 C₃₇H₅₇N₃O₂Si 
• 1619983-84-4 N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)nicotinamide 
• 1619984-52-9 C₃₇H₅₀N₂O₂Si 
• 1619984-51-8 C₃₁H₄₇NOSi 
• 1619984-50-7 C₃₉H₅₅NO₂Si 
• 1619984-49-4 C₃₁H₄₄O₂Si 
• 1619984-48-3 C₃₁H₄₄O₂Si 

Relevant academic research and scientific papers

Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies

Seventeen drimanes including polygodial (1), isopolygodial (2), drimenol (3) and confertifolin (4) obtained from natural sources and the semi-synthetic derivatives 5-17 obtained from 1-3, were evaluated in vitro for antifungal properties against a unique panel of fungi with standardized procedures by using two end-points, MIC100 and MIC50. A SAR analysis of the whole series, supported by conformational and electronic studies, allowed us to show that the Δ7,8 -double bond would be one of the key structural features related to the antifungal activity. The MEPs obtained for active compounds exhibit a clear negative minimum value (deep red zone) in the vicinity of the Δ7,8 -double bond, which is not present in the inactive ones. Apart of this negative zone, a positive region (deep blue) appears in 1, which is not observed either in its epimer 2 nor in the rest of the active compounds. The LogP of active compounds varies between 2.33 and 3.84, but differences in MICs are not correlated with concomitant variations in LogP values.