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10543-42-7

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10543-42-7 Usage

Uses

Different sources of media describe the Uses of 10543-42-7 differently. You can refer to the following data:
1. Coumarin-6-sulfonyl chloride is used to label amines, amino acids and phenols under mild conditions.
2. Coumarin-6-sulfonyl chloride is used as a derivatizing agent for amines and phenols.

Check Digit Verification of cas no

The CAS Registry Mumber 10543-42-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,4 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10543-42:
(7*1)+(6*0)+(5*5)+(4*4)+(3*3)+(2*4)+(1*2)=67
67 % 10 = 7
So 10543-42-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H5ClO4S/c10-15(12,13)7-2-3-8-6(5-7)1-4-9(11)14-8/h1-5H

10543-42-7 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H54767)  Coumarin-6-sulfonyl chloride, 97%   

  • 10543-42-7

  • 1g

  • 553.0CNY

  • Detail
  • Alfa Aesar

  • (H54767)  Coumarin-6-sulfonyl chloride, 97%   

  • 10543-42-7

  • 5g

  • 1379.0CNY

  • Detail
  • Alfa Aesar

  • (H54767)  Coumarin-6-sulfonyl chloride, 97%   

  • 10543-42-7

  • 25g

  • 5510.0CNY

  • Detail

10543-42-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-oxochromene-6-sulfonyl chloride

1.2 Other means of identification

Product number -
Other names 2-Oxo-2H-chromen-6-sulfonylchlorid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10543-42-7 SDS

10543-42-7Related news

Analysis of phenols in water by high-performance liquid chromatography using COUMARIN-6-SULFONYL CHLORIDE (cas 10543-42-7) as a fluorogenic precolumn label08/06/2019

A simple, sensitive and rapid reversed-phase high-performance liquid chromatography (RP-HPLC) method is proposed for the analysis of some environmentally important phenols in water. The use of coumarin-6-sulphonyl chloride (C6SCl) as a fluorescence-labeling reagent has been investigated. The com...detailed

10543-42-7Relevant articles and documents

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

Sabt, Ahmed,Abdelhafez, Omaima M.,El-Haggar, Radwan S.,Madkour, Hassan M. F.,Eldehna, Wagdy M.,El-Khrisy, Ezz El-Din A. M.,Abdel-Rahman, Mohamed A.,Rashed, Laila. A.

, p. 1095 - 1107 (2018)

Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro evaluation of their growth inhibitory activity towards the proliferation of three cancer cell lines; HepG2 (hepatocellular carcinoma), MCF-7 (breast cancer), and Caco-2 (colon cancer). HepG2 cells were the most sensitive cells to the influence of the target coumarins. Compounds 13a and 15a emerged as the most active members against HepG2 cells (IC50 = 3.48 ± 0.28 and 5.03 ± 0.39 μM, respectively). Compounds 13a and 15a were able to induce apoptosis in HepG2 cells, as assured by the upregulation of the Bax and downregulation of the Bcl-2, besides boosting caspase-3 levels. Besides, compound 13a induced a significant increase in the percentage of cells at Pre-G1 by 6.4-folds, with concurrent significant arrest in the G2-M phase by 5.4-folds compared to control. Also, 13a displayed significant increase in the percentage of annexin V-FITC positive apoptotic cells from 1.75–13.76%. Moreover, QSAR models were established to explore the structural requirements controlling the anti-proliferative activities.

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