1054451-08-9Relevant academic research and scientific papers
Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands
Bhattacharjee, Himanshu,Gurley, Steven N.,Moore II, Bob M.
scheme or table, p. 1691 - 1693 (2009/12/03)
A novel series of cannabinoid ligands with a structurally unique tri-aryl core has been designed, synthesized and assayed. Receptor binding assays show that these compounds possess CB2 receptor sub-type selectivity with binding affinities ranging from 1.07 (±0.05) for 7 to 4.77 (±0.57) nM for 6. The selectivity of the compounds was enhanced 9-600-fold for the CB2 receptor over the CB1 receptor. The results of our present study identify a novel, highly selective cannabinoid scaffold with a non-classical core.
Tri-aryl/heteroaromatic cannabinoids and use thereof
-
Page/Page column 19, (2008/12/08)
Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R1, R2, and W can have the definitions provided herein. Without limitation, use of such compounds, their salts or pro-drug, or compositions containing the compounds, salts, or pro-drug, to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.
