1054585-67-9Relevant academic research and scientific papers
Tandem catalytic asymmetric Friedel-Crafts/Henry reaction: Control of three contiguous acyclic stereocenters
Arai, Takayoshi,Yokoyama, Naota
supporting information; experimental part, p. 4989 - 4992 (2009/03/11)
(Chemical Equation Presented) Good things come in threes: Highly functionalized indole derivatives with three contiguous stereocenters were formed in the title reaction of an indole, a nitroalkene, and an aldehyde with the imidazoline-aminophenol catalyst 1-CuOTf in the presence of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). The major isomers of the adducts were obtained with up to 99% ee. Tf = trifluoromethanesulfonyl, Ts = p-toluenesulfonyl; R = H, Me; R′,R″ = alkyl, aryl.
