1054644-73-3

Basic information

• Product Name: (S)-2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethyl-propyl]-benzoylamino}-pentanedioic acid diethyl ester
• CAS NO: 1054644-73-3
• Molecular Weight: 525.648
• Mol File: 1054644-73-3.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethyl-propyl]-benzoylamino}-pentanedioic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethyl-propyl]-benzoylamino}-pentanedioic acid diethyl ester(1054644-73-3)
• EPA Substance Registry System: (S)-2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethyl-propyl]-benzoylamino}-pentanedioic acid diethyl ester(1054644-73-3)

Safety Data

• Hazardous Substances Data: 1054644-73-3(Hazardous Substances Data)

Upstream product

• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 170799-55-0 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoic acid 
• 170799-59-4 tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate 
• 170799-64-1 tert-butyl 4-<3-(2-cyano-3-methoxy-2-cyclopentenyl)-1-ethylpropyl>benzoate 
• 1026443-83-3 4-[3-(2-Cyano-3-oxo-cyclopentyl)-1-ethyl-propyl]-benzoic acid tert-butyl ester 
• 1026491-33-7 4-(1-Ethyl-3-methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester 
• 149325-56-4 tert-butyl 4-(2-ethoxycarbonyl-1-ethylethyl)benzoate 
• 149325-55-3 4-{1-[1-Ethoxycarbonyl-meth-(E)-ylidene]-propyl}-benzoic acid tert-butyl ester 
• 149324-84-5 tert-butyl 4-<3-(1-ethyl-3-iodopropyl)>benzoate 
• 149324-89-0 tert-butyl 4-(3-hydroxy-1-ethylpropyl)benzoate 
• 149324-86-7 4-(t-butoxycarbonyl)propiophenone 

Relevant articles and documents

Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: Bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate

Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl ]benzoyl]-L-glutamic acid (1), have led to the synthesis of