1054722-81-4Relevant articles and documents
Synthesis of AZA analogues of TSAO
Van Nhien, Albert Nguyen,Tomassi, Cyrille,Len, Christophe,Marco-Contelles, Jose Luis,Postel, Denis
, p. 939 - 941 (2003)
TSAO derivatives which were first synthesized in 1992 have shown strong inhibitory effect and selectivity against HIV-1 (Camarasa, M.J.; Perez-Perez, M.J.; San-Felix, A.; Balzarini, J.; De Clercq, E. J. Med. Chem. 1992, 35, 2721-2727). The structure-activ
First synthesis and evaluation of the inhibitory effects of Aza analogues of TSAO on HIV-1 replication
Van Nhien, Albert Nguyen,Tomassi, Cyrille,Len, Christophe,Marco-Contelles, José Luis,Balzarini, Jan,Pannecouque, Christophe,De Clercq, Erik,Postel, Denis
, p. 4276 - 4284 (2007/10/03)
Aza TSAO-T derivatives bearing a dihydroisothiazole dioxide ring instead of an oxathiole dioxide ring at the C-3′ position on the sugar moiety were prepared. We have synthesized four families of compounds depending on substitution at both N-3 and N-2″. Bi