105474-89-3

Upstream product

• 42604-63-7 1,3-dimethyl-2,4,6-trioxohexahydropyrimidine-5-carbaldehyde 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 769-42-6 1,3-dimethylbarbituric acid 
• 139958-85-3 6-hydroxy-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of highly functionalized barbituric acids and study of their interactions with p-glycoprotein and Mg2+ - Potential candidates for multi drug resistance modulation

A number of barbituric acids with appropriate substituent at C-5 position were synthesized and investigated for their interactions with p-gp and Mg2+. Compounds 5, 6, 8-10, 12-14 and 16 increased the basal activity of p-gp by more than 50% at 0

Preparation of 5-formyl- and 5-acetylbarbituric acids, including the corresponding Schiff bases and phenylhydrazones

Simple, effective, and high yield synthetic procedures for formylation and acetylation of barbituric acid derivatives is described. Generated 5-acylbarbituric acids are transformed into the corresponding Schiff bases in high yield condensation reactions with ω-aminoalkanoic acids and nitrophenylhydrazines.