10548-70-6Relevant academic research and scientific papers
Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY
B?rner, Armin,Cunillera, Anton,Diéguez, Montserrat,Godard, Cyril,Lutz, Domke,Margalef, Jessica,Miró, Roger,Pamies, Oscar
, p. 9036 - 9040 (2020)
The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.
Catalytic enantioselective reactions. Part 9. 1,2-O-isopropylidene-5-deoxy-5-N,N-dialkyl (or -N-monoalkyl)amino-α-D-xylofuranose derivatives as highly effective chiral catalysts for enantioselective addition of diethylzinc to aliphatic and aromatic aldehydes
Cho, Byung Tae,Kim, Namdu
, p. 2901 - 2907 (1996)
A series of new 1,2-O-isopropylidene-5-deoxy-5-N,N-dialkyl (or -N-monoalkyl)amino-α-D-xylofuranose derivatives have been prepared from α-D-xylose and their enantioselectivities as chiral catalysts for the addition of diethylzinc to aldehydes have been examined. Of the chiral catalysts examined, 5-deoxy-1,2-O-isopropylidene-5-morpholino-α-D-xylofuranose provides high enantioselectivity for aromatic and relatively hindered aliphatic aldehydes, and 5-deoxy-5-hexahydroazepinyl-1,2-O-isopropylidene-α-D-xylofuranose is highly effective for unhindered aliphatic aldehydes.
