1055025-37-0Relevant academic research and scientific papers
Enantioselective Hydrogenation of Imidazo[1,2-a]pyridines
Schlepphorst, Christoph,Wiesenfeldt, Mario P.,Glorius, Frank
, p. 356 - 359 (2018)
The enantioselective synthesis of tetrahydroimidazo[1,2-a]pyridines by direct hydrogenation was achieved using a ruthenium/N-heterocyclic carbene (NHC) catalyst. The reaction forgoes the need for protecting or activating groups, proceeds with complete regioselectivity, good to excellent yields, enantiomeric ratios of up to 98:2, and tolerates a broad range of functional groups. 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridines, which are found in numerous bioactive molecules, were directly obtained by this method, and its applicability was demonstrated by the (formal) synthesis of several functional molecules.
Iron(III)-Catalyzed Cascade Reaction between Nitroolefins and 2-Aminopyridines: Synthesis of Imidazo[1,2-a]pyridines and Easy Access towards Zolimidine
Santra, Sougata,Bagdi, Avik Kumar,Majee, Adinath,Hajra, Alakananda
, p. 1065 - 1070 (2013)
The iron(III)-catalyzed one-pot cascade reaction between nitroolefins and 2-aminopyridines has been demonstrated for the synthesis of imidazo[1,2-a] pyridines by exploiting the bielectrophilic nature of nitroolefins. This methodology could be successfully
Peroxide-mediated site-specific C-H methylation of imidazo[1,2-: A] pyridines and quinoxalin-2(1 H)-ones under metal-free conditions
Jin, Shengzhou,Yao, Hua,Lin, Sen,You, Xiaoqing,Yang, Yao,Yan, Zhaohua
supporting information, p. 205 - 210 (2020/01/13)
An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free conditions is described. In this protocol, peroxides serve as both the radical initiator and methyl source. Methylated imidazopyridines and quinoxalin-2(1H)-ones were smoothly synthesized in moderate to good yields. A free radical reaction mechanism was proposed to describe the methylation process.
Synthesis of novel N,N-dimethyl-1-(5-methyl-2-arylimidazo[1,2-a]pyridin-3-yl) methanamine derivatives as potential antimicrobial agents
Desai,Pandya,Patel,Bhatt,Karkar
, p. 1136 - 1143 (2017/04/28)
The title compounds NnN-dimethyl-l-(5-methyl-2-arylimidazo[l,2-a]pyridin-3-yl)methanamines have been synthesized by reaction of α-haloketones with 6-methylpyridin-2-amine followed by a series of multistep reactions giving the targeted compounds (4a-l). All the synthesized compounds have been screened for their in vitro antibacterial activity against E. coli, S. aureus, P. aeruginosa, S. pyogenes and antifungal activity against C. albicans, A. Niger and A. clavatus. The structures of the synthesized compounds have been confirmed by spectral data IR, 1H and 13C NMR and mass spectra. Investigation of antimicrobial activity reveals that the compounds 4b, 4c, 4d, 4e and 4j show significant activities against tested organisms as compared to standard drugs like ampicillin and griseofulvin.
