1055029-11-2

Upstream product

• 264132-25-4 (1S,2S,3E)-1-[(1S)-1-benzyloxymethoxyethyl]-2-hydroxy-5-(p-methoxybenzyloxypent-3-enyloxy)acetic acid tert-butyl ester 

Downstream Products

• 264132-29-8 (2S,3S,6R)-6-[(1S)-1-benzyloxymethoxyethyl]-3-p-methoxybenzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 
• 264132-52-7 C₅₉H₇₇Cl₃O₁₆Si 
• 264132-55-0 C₅₃H₆₃Cl₃O₁₆ 
• 264132-58-3 C₅₁H₆₂O₁₆ 
• 264132-21-0 C₅₁H₆₀O₁₅ 
• 264132-46-9 C₄₂H₅₇Cl₃O₁₁Si 
• 264132-49-2 C₃₆H₄₃Cl₃O₁₁ 
• 264132-34-5 (2S,3S,6R)-6-[(1S)-1-(tert-butyldimethylsiloxy)ethyl]-3-p-methoxybenzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester 
• 264132-31-2 (2S,3S,6R)-6-[(1S)-1-benzyloxymethoxyethyl]-3-p-methoxybenzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester 
• 264132-35-6 (2S,3S,6R)-6-[(1S)-1-(tert-butyldimethylsiloxy)ethyl]-3-p-methoxybenzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 
• 264132-33-4 (2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-p-methoxybenzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester 

Relevant academic research and scientific papers

Synthesis and Study of C3-Symmetric Hydropyran Cyclooligolides with Oriented Aryl and Alcohol Appendages at 10 A Spacing

Modular syntheses of C3-symmetric macrocycles with pendant aryl and hydroxymethyl groups are described. These functional groups, amenable to further elaboration, were installed early in each synthesis and carried through an iterative sequence of module coupling and macrolactonization. Association constants for macrolides 1a-c with alkali metal cation guests were determined, and sandwich-type complexes with Ba2+ were confirmed for these macrocycles based on 1H NMR studies, including Job plots. X-ray crystallographic data for macrolides 1a and 1c were obtained and are discussed in detail. These data provide support that the macrolides are structurally well-defined and preorganized for binding the potassium cation. Preparation of the tris(bromoacetylated) macrotriolide 43 exemplifies a functionalized platform suitable for elaboration with peptide or carbohydrate residues.