1055034-47-3

Upstream product

• 1016508-08-9 6-Amino-hexanoic acid 4-methoxy-benzylamide 
• 67010-43-9 (3S,4S)-ethyl 4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoate 
• 58521-49-6 (3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid 

Downstream Products

• 189163-06-2 {5-[(S)-1-[(S)-2-(1-Benzyl-1H-imidazol-4-yl)-1-((S)-1-{(S)-1-hydroxy-2-[5-(4-methoxy-benzylcarbamoyl)-pentylcarbamoyl]-ethyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester 
• 1053696-38-0 {5-[(S)-1-[(S)-1-((S)-1-{(S)-1-Hydroxy-2-[5-(4-methoxy-benzylcarbamoyl)-pentylcarbamoyl]-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester 
• 1054645-95-2 (3S,4S)-4-[(S)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)-propionylamino]-3-hydroxy-6-methyl-heptanoic acid [5-(4-methoxy-benzylcarbamoyl)-pentyl]-amide 
• 189163-05-1 [(S)-2-(1-Benzyl-1H-imidazol-4-yl)-1-((S)-1-{(S)-1-hydroxy-2-[5-(4-methoxy-benzylcarbamoyl)-pentylcarbamoyl]-ethyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

New renin inhibitors containing aliphatic or aromatic amides at the C-terminus

Five renin inhibitors, Iva-Pro-Phe(4-OMe)-MeLeu-Sta-εAhx-IAA (18), Iva-εAhx-Phe(4-OMe)-MeLeu-Sta-εAhx-IAA (23), H-εAhx-Phe(4-OMe)-His-Sta-εAhx-FBZA (36), H-εAhx-Phe(4-OMe)-His-Sta-εAhx-MBZA (45), and H-Phe (4-OMe)-His-Sta-εAhx-FBZA (48) have been synthesized in search of structures of improved biological properties. All synthesized inhibitors were resistant to chymotrypsin activity. Inhibitors 18 and 23 were insoluble in buffers, pH 7.4 and 2.0, 36, 45 and 48 were very good soluble in buffer pH 2.0 and poorly in buffer pH 7.4. Experimentally determined 1-octanol/pH 7.4 buffer partition coefficients (log P) of 36, 45 and 48 were above 1. Log P values of 18, 23, 36, 45 and 48 were 6.57, 6.91, 2.48, 2.09 and 2.00 respectively. The inhibitory potency in vitro of 18, 23, 36, 45 and 48 expressed as IC50 was 7.5 · 10-5, 5.0 · 10-6, 7.5 · 10-3, 1.0 · 10-4 and 2.5 · 10-5 M/l respectively.