1055039-72-9Relevant academic research and scientific papers
New Acyclic Nucleoside Analogues. Stereospecific Synthesis of Purines and Pyrimidines Substituted with Chiral Chains by Sugar-ring Opening of &β-D-Galactopyranosyl Nucleosides
El-Kattan, Yahya,Gosselin, Gilles,Imbach, Jean-Louis
, p. 1289 - 1298 (2007/10/02)
2',3'- and 3',4'-Seco-nucleosides, retaining the carbon framework of β-D-ribofuranosyl nucleosides but having a hydroxymethyl substituent on the 4' or 5' position, have been synthesized and their antiviral properties examined.These hitherto unknown chiral acyclic nucleosides were stereospecifically prepared by ring opening of β-D-galactopyranosyl nucleosides by means of periodate oxidation followed by borohydride reduction.None of the prepared compounds showed marked antiviral effect against a variety of DNA and RNA viruses.
