10551-05-0Relevant academic research and scientific papers
Thiono and Dithio Esters, 44. - Reaction of Tetrathiomalonic Esters with Amines, Hydrazines and Oxidizing Agents
Afrashteh, Ali,Hartke, Klaus
, p. 909 - 912 (1988)
The reaction of diethyl tetrathiomalonate (1) with primary and secondary aliphatic amines leads to the formation of the malonic acid dithioamides 2; with primary aromatic amines the β-amino dithioacrylates 3 were isolated.Cyclisation of 1 with methyl and
Thiono and Dithio Esters, 40. - Reactions of Dithionomalonic Esters with Nucleophilic Nitrogen Bases
Hartke, Klaus,Mueller, Heinz-Georg
, p. 863 - 871 (2007/10/02)
Dithionomalonic esters 1, obtained from malonitrile via malonodiimidium salts 5 by thiolysis, react with amines under elimination of H2S to form the 3-amino-thioacrylic O-esters 11.The alkali salts of 1 condense with amines to give the malonodithioamides 12 by loss of 2 molecules of alcohol.Oxidative cyclization of 11 leads to the isothiazoles 16-18.Reaction of 1 with hydrazines gives rise to the pyrazoles 20-22; with amidines the pyrimidines 23 and 24 were obtained.
