105528-25-4Relevant articles and documents
Dual Function Antibody Conjugates for Multimodal Imaging and Photoimmunotherapy of Cancer Cells
Saad, Mohammad A.,Xavierselvan, Marvin,Sharif, Hamza A.,Selfridge, Scott,Pawle, Robert,Varvares, Mark,Mallidi, Srivalleesha,Hasan, Tayyaba
, p. 220 - 231 (2021/08/26)
Precision imaging, utilizing molecular targeted agents, is an important tool in cancer diagnostics and guiding therapies. While there are limitations associated with single mode imaging probes, multimodal molecular imaging probes enabling target visualization through complementary imaging technologies provides an attractive alternative. However, there are several challenges associated with designing molecular probes carrying contrast agents for complementary multimodal imaging. Here, we propose a dual function antibody conjugate (DFAC) comprising an FDA approved photosensitizer Benzoporphyrin derivative (BPD) and a naphthalocyanine-based photoacoustic dye (SiNc(OH)) for multimodal infrared (IR) imaging. While fluorescence imaging, through BPD, provides sensitivity, complementing it with photoacoustic imaging, through SiNc(OH), provides a depth-resolved spatial resolution much beyond the optical diffusion limits of fluorescence measurements. Through a series of in?vitro experiments, we demonstrate the development and utilization of DFACs for multimodal imaging and photodynamic treatment of squamous cell carcinoma (A431) cell line. The proposed DFACs have potential use in precision imaging applications such as guiding tumor resection surgeries and photodynamic treatment of residual microscopic disease thereby minimizing local recurrence. The data demonstrated in this study merits further investigation for its preclinical and clinical translation.
COMPOSITION, AND PHOTOELECTRIC CONVERSION ELEMENT AND IMAGING DEVICE THAT EMPLOY THE SAME
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Paragraph 0134; 0136; 0137; 0138; 0139; 0140, (2019/01/23)
PROBLEM TO BE SOLVED: To provide a composition, a photoelectric conversion element and an imaging device which have high light absorption characteristics in the near-infrared region and exhibit high photoelectric conversion efficiency. SOLUTION: A composition contains a compound represented by the general formula in the figure, where M represents either Si or Sn; R1 to R8 each independently represent an alkyl group containing three or less carbon atoms; and R9 to R14 each independently represent an alkyl group. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
Synthesis of a series of octabutoxy- and octabutoxybenzophthalocyanines and photophysical properties of two members of the series
Aoudia, Mohamed,Cheng, Gongzhen,Kennedy, Vance O.,Kenney, Malcolm E.,Rodgers, Michael A. J.
, p. 6029 - 6039 (2007/10/03)
We have developed a new route to silicon-centered phthalocyanines and phthalocyanine-like compounds that is robust and flexible, and of considerable potential usefulness. This route entails insertion of silicon into the metal-free macrocycle. It has been developed in the course of preparing four new and two known metal-free, six new dihydroxysilicon, and six new bis-trihexylsiloxysilicon octabutoxy- and octabutoxybenzophthalocyanines. One of the siloxysilicon compounds, that with the ligand 5,9,12,16,19,23,28,32-octabutoxy-33H,35H- dibenzo[b,g]dinaphtho[2,3-1:2',3'-q]porphyrazine, has a Q-band at a wavelength of 804 nm and an extinction coefficient of 1.9 x 105 M-1 cm- 1. Its wavelength thus matches the wavelength of the output of the most common GaA1As diode laser. The compound and its analog in which the benzo rings are trans to each other instead of cis have no tendency to aggregate in benzene up to a concentration of 150 μM. The triplet state of the cis isomer has an absorption maximum at 640 nm and a lifetime in deaerated benzene solution of 105 μs, while the triplet state of the trans isomer has a maximum at 660 nm and a lifetime of 72 μs. Both isomers have a triplet quantum yield, Q1, of ca. 0.20 and a singlet oxygen quantum yield, Q(Δ), of ca, 0.20, photochemical properties that are consistent with potentially efficient photosensitization action in photodynamic therapy of tumors. For both sensitizers, energy transfer from the sensitizer triplet to ground state of dioxygen is reversible at appropriate concentrations. For the cis isomer, the equilibrium constant for the energy transfer process, K(e), is 0.012 ± 0.001, and the triplet state energy calculated from this, E(T), is 21.29 kcal/mol (E(T) derived from phosphorescence measurements is 21.26 kcal/mol). For the trans isomer, K(e) is 3.68 x 10-3 and E(T) is 19.27 kcal/mol.
