1055328-74-9Relevant articles and documents
Stereoselective desymmetrisation of prochiral α,α- dicyanoalkenes via domino Michael-Michael addition reactions
Kang, Tai-Ran,Xie, Jian-Wu,Du, Wei,Feng, Xin,Chen, Ying-Chun
supporting information; experimental part, p. 2673 - 2675 (2009/02/02)
The desymmetrisation of prochiral α,α-dicyanoalkenes via tandem Michael-Michael addition reactions with α,β-unsaturated ketones catalysed by 9-amino-9-deoxyepicinchona alkaloids was investigated, from which bicyclic products bearing four stereogenic centers were afforded in a single operation with high stereoselectivities (>99% de, up to >99.5% ee). The Royal Society of Chemistry.