105552-22-5Relevant academic research and scientific papers
Thiophene 1,1-dioxide: Synthesis, isolation, and properties
Nagasawa, Hidehiro,Sugihara, Yoshiaki,Ishii, Akihiko,Nakayama, Juzo
, p. 1919 - 1926 (2007/10/03)
Oxidation of thiophene with dimethyldioxirane at -20 °C and removal of the solvent and volatile materials below -40 °C allowed the isolation of the parent thiophene 1,1-dioxide (1) as colorless crystals in pure form. The 1,1- dioxide 1, which had eluded isolation for a long time despite many efforts, melted at about 6 °C and the melt solidified at room temperature because of the dimeric and trimeric products formation. The structure of 1 was fully characterized by 1H- and 13C NMR, IR, Raman, UV/vis, and Mass spectroscopies. The decomposition of 1 in solution provided the dimer (7) as the principal product along with the trimer (9), whereas the decomposition of a neat sample furnished 7 and 9 in comparable amounts. The half-life of 1 is dependent upon the concentration of 1; 137 and 747 min at 25 °C in 0.12 and 0.025 M CDCl3 solutions (1 M = 1 mol dm-3), respectively. Kinetics of the dimerization of 1 in a dilute solution provided the activation parameters of E(n) = 64.4 (±0.3) kJ mol-1, ΔH(≠) = 62.0 (+0.3) kJ mol-1, and ΔS(≠) = -59.8 (± 1.0) J K-1 mol-1. Attempted reactions of 1 with a series of dienophiles and dienes all failed because the dimerization of 1 is much faster than reactions with these additives. An exception is the reaction with cyclopentadiene which gave the Diels-Alder adduct in good yield. The adduct of the dimer 7 with dimethyl acetylenedicarboxylate was found to undergo a retro Diels-Alder reaction to regenerate 1.
COMPARATIVE STUDIES ON SYNTHESIS AND PROPERTIES OF PHOSPHORUS AND SULFUR HETEROCYCLES: THE HETERONIN OXIDE SYSTEM
Quin, Louis D.,Rao, N.S.,Szewczyk, Jerzy
, p. 109 - 118 (2007/10/02)
Phosphonin oxides are the first recognizable product on reaction of 9-phosphabicyclonona-2,4,6-trienes with peroxides at -15 deg C. These compounds (R=C6H5 or t-C4H9) are stable below -15 deg C, but undergo intramolecular cycloaddition to
Thionin Oxide as a Possible Intermediate on Periodate Oxidation of 9-Thiabicyclonona-2.4.6-triene
Quin, Louis D.,Rao, Nandakumar S.,Szewczyk, Jerzy
, p. 6293 - 6296 (2007/10/02)
9-Thiabicyclonona-2,4,6-triene was oxidized at -15 to -20 deg C with sodium periodate in a methanol-water medium.The major isolated product was established as cis-3a,7a-dihydrobenzothiophene-cis-1-oxide, which is best explained as arising from intramolecular cycloaddition of a thionin oxide intermediate.
