10557-21-8

Basic information

• Product Name: 1-(4-Chlorophenyl)-1,2-propandione
• Synonyms: 1-(4-CHLOROPHENYL)PROPANE-1,2-DIONE;1-(4-CHLOROPHENYL)-1,2-PROPANDIONE;1-(4-CHLOROPHENYL)-1,2-PROPANEDIONE;Chlorophenylpropandione 1412()----;4-Chloro-2'-oxopropiophenone;4'-Chloro-2-oxopropiophenone, 1-(4-Chlorophenyl)-1,2-dioxopropane
• CAS NO: 10557-21-8
• Molecular Formula: C₉H₇ClO₂
• Molecular Weight: 182.6
• Mol File: 10557-21-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 30-32
• Boiling Point: 60-65/0.02bar
• Flash Point: 115 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 0.00474mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4-Chlorophenyl)-1,2-propandione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-1,2-propandione(10557-21-8)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-1,2-propandione(10557-21-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 10557-21-8(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-1,2-propandione, also known as 4-Chloro-1-phenyl-1,2-propanedione or 4-Chloro-1-phenyl-1,2-propanedione, is a chemical compound with the molecular formula C9H7ClO2. It is a yellow solid with a melting point of 91-94°C. 1-(4-Chlorophenyl)-1,2-propandione is commonly used as a reagent in organic synthesis and pharmaceutical research. It is a versatile building block for the synthesis of various compounds due to its unique chemical properties. Additionally, it exhibits antibacterial and antifungal properties, making it useful in the development of pharmaceuticals. However, it is important to handle this compound with caution due to its potential health hazards and irritant properties.

InChI:InChI=1/C9H7ClO2/c1-6(11)9(12)7-2-4-8(10)5-3-7/h2-5H,1H3

Upstream product

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Downstream Products

• 132497-15-5 2-dimethylamino-3-formyl-4-chloro-5-(4-chlorphenyl)furan 
• 1221265-66-2 3-(4-chlorophenyl)-2-methylquinoxaline-5-carbonitrile 
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• 1221265-68-4 3-(4-chlorophenyl)-5-methoxy-2-methylquinoxaline 
• 1221265-67-3 2-(4-chlorophenyl)-5-methoxy-3-methylquinoxaline 
• 1221265-57-1 2-(4-chlorophenyl)-3-methyl-5-(trifluoromethyl)quinoxaline 
• 1221265-58-2 3-(4-chlorophenyl)-2-methyl-5-(trifluoromethyl)quinoxaline 
• 1279712-74-1 N-(3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl)acetamide 
• 16616-42-5 p-chlorobenzoylphenylacetylene 
• 4998-15-6 4-chlorophenylglyoxal 
• 89201-19-4 3-acetyl-1-(4'-chlorophenyl)-2-pentene-1,4-dione 
• 1602935-24-9 (E)-1-(4-chlorophenyl)-4-phenylbut-3-ene-1,2-dione 

Relevant articles and documents

Cobalt(II) Chloride Catalysed Coupling of Acetic Anhydride with Aldehydes. A Novel Synthesis of Asymmetrical 1,2-Diones

Cobalt(II) chloride in acetonitrile efficiently catalyses the coupling of acetic anhydride with various aldehydes to the corresponding 1,2-diones in very high yields.

Ozonolysis of Alkynes - A Flexible Route to Alpha-Diketones: Synthesis of AI-2

A mild procedure for the low-temperature conversion of alkynes to diketones has been developed and employed in the synthesis of AI-2.

A new synthetic route for 1,2-diketo compounds using unexpected C-C bond cleavage by PCC

An efficient method has been established for the preparation of 1,2-diketones by unexpected C-C bond cleavage in 4-keto-2-hydroxy esters using pyridiniumchlorochromate (PCC).

New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation

Asymmetric hydrogenation of α-dehydroamino ketones catalyzed by a rhodium-chiral phosphorus ligand complex (up to 99% ee, 1000 TON), represents an efficient approach to chiral α-amino ketones. The reduction of α-amino ketones catalyzed by palladium on carbon (Pd/C) leads to amphetamine precursors with quantitative yield and no significant enantioselectivity loss.