10557-76-3Relevant academic research and scientific papers
Isomerizable (: E / Z)-alkynyl- O -methyl oximes employing TMSCl-NCS in chlorinative cyclization for the direct synthesis of 4-chloroisoxazoles
Kaewsri, Wilailak,Thongsornkleeb, Charnsak,Tummatorn, Jumreang,Ruchirawat, Somsak
, p. 48666 - 48675 (2016/06/09)
For the first time, 4-chloroisoxazoles are directly synthesized in moderate to excellent yields from (E/Z)-alkynyl-O-methyl oximes via chlorinative cyclization. The synthesis employs the combination of N-chlorosuccinimide (NCS) and chlorotrimethylsilane (
SYNTHESIS OF 5-AMINO-4-CHLORO-4,5-DIHYDROISOXAZOLES AND 4-CHLOROISOXAZOLES.
Barluenga, Jose,Tomas, Miguel,Lopez, Luis Angel,Jardon, Jesus,Gotor, Vicente
, p. 1763 - 1774 (2007/10/02)
4-Chloro-4,5-dihydroisoxazoles (4) and (5) and -isoxazoles (6) were prepared by reaction of chlorodiimines (1) and (2) with hydroxylamine hydrochloride.Basic treatment of (5) gave rise to N-N bond formation yielding pyrazoles (8).
