105576-04-3Relevant academic research and scientific papers
A NOVEL SYNTHESIS OF CYCLOPENTENONES AND CYCLOHEXENONES VIA CYCLIACYLATION OF LITHIOALKENYLCARBOXAMIDES
Sawada, Hiroyuki,Webb, Michael,Stoll, A. Timothy,Negishi, Ei-ichi
, p. 775 - 778 (2007/10/02)
The reaction of 1-iodo-3-bromopropene derivatives (1) with lithium enolates of N,N-dialkylcarboxamides followed by treatment of the allylation product (2) with two equiv of t-BuLi cleanly provides cyclopentenones in high yields, while the corresponding cycliacylation reaction of 6-iodo-5-hexenamides provides cyclohexenones.
