1055896-22-4Relevant academic research and scientific papers
Discovery of biphenylketones as dual modulators of inflammation and bone loss
Greig, Iain R.,Coste, Emmanuel,Ralston, Stuart H.,Van'T Hof, Rob J.
supporting information; experimental part, p. 5548 - 5551 (2010/12/29)
Biphenylketones were identified as novel inhibitors of NFκB activation. Structure-activity studies led to the identification of compound 4c, which had good potency against osteoclasts (IC50 = 0.8 μM), showed oral activity, and was able to compl
